Understanding how cannabidiol (CBD) exerts its myriad effects on human physiology is a work in progress. Thus far, scientists have identified more than 60 different molecular pathways through which CBD operates. It is known, for example, that CBD acts through multiple receptor-independent channels and it also binds to various receptors in the brain, including serotonin 5HT1A (which contributes to CBD’s antidepressant effect), TRPV1 (which contributes to CBD’s anti-psychotic effect), the nuclear receptor PPAR-gamma (regulates gene expression), and the orphan receptor GPR55, among others.
Professor Greg Gerdeman on brain science, the neurobiology of stress, and how the discovery of the endocannabinoid system has liberated cannabis from the drug abuse paradigm. Here is a wonderful interview with Professor Gerdeman with Project CBD:
Employers across the country are finding it difficult to hire potential job candidates who are willing and able to pass drug tests, according to a New York Times report by Jackie Calmes.
While the problem hits unskilled or low-skilled workers more, it also impacts higher-skilled jobs, Calmes said. She said marijuana remains the biggest culprit for candidates not passing drug tests.
We have a pesky, non-organic thorn in our side. Our current agricultural system is not based on sustainable means of cultivation and, unfortunately, this also applies to much of cannabis farming today. While the “organic” marijuana movement is gaining momentum, the vast majority of cultivators grow cannabis as a monocultural crop, which often entails the use of toxic pesticides and plant growth boosters to maximize profit.
A new study has concluded that state tests of the impairment of drivers who have smoked cannabis do not have any scientific basis.
The study released Tuesday by the AAA Foundation for Traffic Safety found that drivers can have a low level of THC, the active ingredient in marijuana, in their blood and be unsafe behind the wheel, while others with relatively high levels may not be a hazard.
Coffee, tea, and alcohol are probably the most socially-condoned addictions in the Western world. But as smoking a J rapidly becomes almost as normal as a morning cup of joe, many people are doubling-on and combining their low-level vices.
Using THC and caffeine in tandem doesn’t cause the wooziness many people get when they drink and smoke at the same time. But caffeine and THC still work together in surprising, if less-intense, ways.